Nexus - an open global infrastructure for spatial-aware applications

Due to the lack of a generic platform for location- and spatial-aware systems, many basic services have to be reimplemented in each application that uses spatial-awareness. A cooperation among different applications is also difficult to achieve without a common platform. In this paper we present a platform that solves these problems. It provides an infrastructure that is based on computer models of regions of the physical world, which are augmented by virtual objects. We show how virtual objects make the integration of existing information systems and services in spatial-aware systems easier. Furthermore, our platform supports interactions between the computer models and the real world and integrates single models in a global 'Augmented World'

Social media mining under the COVID-19 context: Progress, challenges, and opportunities

Social media platforms allow users worldwide to create and share information, forging vast sensing networks that allow information on certain topics to be collected, stored, mined, and analyzed in a rapid manner. During the COVID-19 pandemic, extensive social media mining efforts have been undertaken to tackle COVID-19 challenges from various perspectives. This review summarizes the progress of social media data mining studies in the COVID-19 contexts and categorizes them into six major domains, including early warning and detection, human mobility monitoring, communication and information conveying, public attitudes and emotions, infodemic and misinformation, and hatred and violence. We further document essential features of publicly available COVID-19 related social media data archives that will benefit research communities in conducting replicable and repro�ducible studies. In addition, we discuss seven challenges in social media analytics associated with their potential impacts on derived COVID-19 findings, followed by our visions for the possible paths forward in regard to social media-based COVID-19 investigations. This review serves as a valuable reference that recaps social media mining efforts in COVID-19 related studies and provides future directions along which the information harnessed from social media can be used to address public health emergencies

Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model

Background High night-to-night variability in obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Obstructive apneas are characterized by intermittent deoxygenation-reoxygenation and intrathoracic pressure swings during ineffective inspiration against occluded upper airways. Objective We elucidated the effect of repeated exposure to transient OSA conditions simulated by intermittent negative upper airway pressure (INAP) on the development of an AF substrate. Methods INAP (48 events/4 h; apnea-hypopnea index 12 events/h) was applied in sedated spontaneously breathing rats (2% isoflurane) to simulate mild-to-moderate OSA. Rats without INAP served as a control group (CTR). In an acute test series (ATS), rats were either killed immediately (n = 9 per group) or after 24 hours of recovery (ATS-REC: n = 5 per group). To simulate high night-to-night variability in OSA, INAP applications (n = 10; 24 events/4 h; apnea-hypopnea index 6/h) were repeated every second day for 3 weeks in a chronic test series (CTS). Results INAP increased atrial oxidative stress acutely, represented in decreases of reduced to oxidized glutathione ratio (ATS: INAP: 0.33 ± 0.05 vs CTR: 1 ± 0.26; P = .016), which was reversible after 24 hours (ATS-REC: INAP vs CTR; P = .274). Although atrial oxidative stress did not accumulate in the CTS, atrial histological analysis revealed increased cardiomyocyte diameters, reduced connexin 43 expression, and increased interstitial fibrosis formation (CTS: INAP 7.0% ± 0.5% vs CTR 5.1% ± 0.3%; P = .013), which were associated with longer inducible AF episodes (CTS: INAP: 11.65 ± 4.43 seconds vs CTR: 0.7 ± 0.33 seconds; P = .033). Conclusion Acute simulation of OSA was associated with reversible atrial oxidative stress. Cumulative exposure to these transient OSA-related conditions resulted in AF substrates and was associated with increased AF susceptibility. Mild-to-moderate OSA with high night-to-night variability may deserve intensive management to prevent atrial substrate development

Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells

Peer reviewedPublisher PD

Regulation of the Transglutaminase I gene

The transglutaminase I (TGase I) gene encodes an enzyme that catalyzes the cross-linking of structural proteins involved in the formation of the cornified envelope during squamous cell differentiation. To identify DNA elements important for the transcriptional control of the TGase I gene, we analyzed the ability of a 2.9-kilobase pair (kb) upstream regulatory region to control the expression of a reporter gene in vivo and in vitro. Transgenic mice bearing the pTG(-2.9kb)CAT construct exhibited the same pattern of tissue-specific expression of CAT as reported for TGase I. Deletion analysis in transiently transfected rabbit tracheal epithelial cells indicated that two sequences from bp -490 to -470 and from -54 to -37 are involved in the activation of TGase I transcription. Point mutation analysis and mobility shift assays showed that the sequence located between -54 and -37 is a functional Sp1-like transcription element. Sp1 and Sp3, but not Sp2, are part of nuclear protein complexes from differentiated RbTE cells binding to this site. The element TGATGTCA between bp -490 and -470 is contained in a larger 22-bp palindrome and resembles the consensus cAMP response element-binding protein (CREB)/AP-1 element recognized by dimeric complexes of members of the CREB, ATF, Fos, and Jun families. Mutations in this sequence greatly reduced promoter activity. Supershift analysis identified CREB1, JunB, c-Fos, Fra-1, and c-Jun in protein complexes isolated from differentiated rabbit tracheal epithelial cells binding to this site. Our study shows that the Sp1- and CREB/AP-1-like sites act in concert to stimulate transcription of the TGase I gene. The 2.9-kb promoter region could guide expression of specific genes in the granular layer of the epidermis and could be useful in gene therapy

Galaxy bulges and their massive black holes: a review

With references to both key and oft-forgotten pioneering works, this article starts by presenting a review into how we came to believe in the existence of massive black holes at the centres of galaxies. It then presents the historical development of the near-linear (black hole)-(host spheroid) mass relation, before explaining why this has recently been dramatically revised. Past disagreement over the slope of the (black hole)-(velocity dispersion) relation is also explained, and the discovery of sub-structure within the (black hole)-(velocity dispersion) diagram is discussed. As the search for the fundamental connection between massive black holes and their host galaxies continues, the competing array of additional black hole mass scaling relations for samples of predominantly inactive galaxies are presented.Comment: Invited (15 Feb. 2014) review article (submitted 16 Nov. 2014). 590 references, 9 figures, 25 pages in emulateApJ format. To appear in "Galactic Bulges", E. Laurikainen, R.F. Peletier, and D.A. Gadotti (eds.), Springer Publishin

Analyzing Factors that Affect Commuter Mode Choice: ‘Can the Development of Viable Alternative Mode Choice and Proper Incentivization Lead to Lower Levels of Automobile Commuting?’ Case Study: Washington-Arlington-Alexandria Metropolitan Statistical Area

Municipalities, planners, and governmental decision makers in the US attempt to reduce commuting by automobile by building the highest functioning and most extensive public transportation systems possible in their given city. Unfortunately, the old adage, ‘if you build it, they will come’ is not true in regard to shifting commuter mode choice. For a real shift to occur, workers must be incentivized to use the alternative modes of transportation that are available. This study evaluates the relationship between the development of viable modal choice and proper incentivization, and mode choice for the commute to work using five-year averaged census data for the 1220 census tracts in the Washington, DC region. In addition, this study uses planning and financial documents from the Metropolitan Council of Governments and the Washington Metropolitan Area Transit Authority. Multivariate regression results show highly significant relationships between the use of public transportation, biking, and walking and our explanatory variables: proximity to a station, population density, educational attainment, income, and race. Through our case study evaluation, we have concluded that the Washington-Arlington- Alexandria Metropolitan Statistical Area has one of the premier transportation systems in the country

A Geographical Analysis of Socioeconomic and Environmental Drivers of Physical Inactivity in Post Pandemic Cities: The Case Study of Chicago, IL, USA

The pandemic’s lockdown has made physical inactivity unavoidable, forcing many people to work from home and increasing the sedentary nature of their lifestyle. The link between spatial and socio-environmental dynamics and people’s levels of physical activity is critical for promoting healthy lifestyles and improving population health. Most studies on physical activity or sedentary behaviors have focused on the built environment, with less attention to social and natural environments. We illustrate the spatial distribution of physical inactivity using the space scan statistic to supplement choropleth maps of physical inactivity prevalence in Chicago, IL, USA. In addition, we employ geographically weighted regression (GWR) to address spatial non-stationarity of physical inactivity prevalence in Chicago per census tract. Lastly, we compare GWR to the traditional ordinary least squares (OLS) model to assess the effect of spatial dependency in the data. The findings indicate that, while access to green space, bike lanes, and living in a diverse environment, as well as poverty, unsafety, and disability, are associated with a lack of interest in physical activities, limited language proficiency is not a predictor of an inactive lifestyle. Our findings suggest that physical activity is related to socioeconomic and environmental factors, which may help guide future physical activity behavior research and intervention decisions, particularly in identifying vulnerable areas and people